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RNF126 and the dedifferentiation of liver cancer |
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An article in PNAS describes how hypoxia and the elimination of peroxisomes drives HCC dedifferentiation, a hallmark of malignancy and a challenge for therapy. The E3 ubiquitin ligase RNF126 is identified as a hypoxia-inducible switch that determines peroxisomal fate and links the hypoxic microenvironment to loss of hepatocyte differentiation.... Read more |
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